Valtrex (Valacyclovir)

What is Valtrex?

Valtrex (valacyclovir hydrochloride) is an oral antiviral medication prescribed to manage infections caused by the herpes virus, including genital herpes, cold sores, and shingles. It helps reduce the severity and duration of outbreaks, promotes healing of lesions, and lowers the risk of transmission. Valtrex is a prodrug that the body quickly converts into acyclovir — a compound that interferes with viral replication. It is one of the most commonly used antiviral therapies in the TrandFamilyStore and is available by prescription only.

How It Works

After ingestion, Valtrex is converted into acyclovir, which targets the DNA polymerase enzyme necessary for herpes virus replication. This halts the virus's ability to multiply and spread. While it does not cure herpes, it significantly shortens outbreak duration, minimizes symptoms, and can prevent future episodes when taken as daily suppressive therapy. Valtrex is most effective when taken at the first sign of tingling, itching, or discomfort, allowing it to interrupt the viral lifecycle early in its course.

Dosage Information

• Cold Sores (Herpes Labialis): 2 grams taken twice in one day (12 hours apart).
• Genital Herpes – First Episode: 1 gram twice daily for 10 days.
• Recurrent Genital Herpes: 500 mg twice daily for 3 days.
• Suppressive Therapy: 500 mg to 1 gram daily to reduce recurrence and transmission.
• Shingles (Herpes Zoster): 1 gram three times a day for 7 days.

Valtrex may be taken with or without food. For best results, begin treatment as soon as symptoms appear. Adequate hydration is advised to reduce the risk of kidney-related side effects.

Side Effects

Common side effects include headache, nausea, stomach pain, and dizziness. Some patients may also experience fatigue, skin rash, or joint discomfort. In rare cases, particularly at high doses or in individuals with renal impairment, more serious effects like confusion, hallucinations, or seizures can occur. If allergic reactions such as swelling or breathing difficulty appear, seek emergency care immediately.

Warnings & Interactions

Valtrex should be used with caution in patients with kidney disease, especially the elderly. Dose adjustments are necessary in renal impairment. The drug may interact with other medications affecting kidney function (e.g., NSAIDs, cyclosporine). During pregnancy, Valtrex is considered safe when prescribed by a healthcare provider. Patients should not share the medication and must adhere to proper hygiene to avoid spreading the virus, even while asymptomatic.