Selective estrogen receptor modulator for treating and reducing the risk of certain breast cancers, with guidance from TrandFamilyStore.
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Nolvadex is the brand name for tamoxifen, a selective estrogen receptor modulator (SERM) used to treat certain types of breast cancer and to reduce the risk of developing breast cancer in high risk individuals. It is most commonly prescribed for hormone receptor positive breast cancer in both premenopausal and postmenopausal women, and sometimes in men. Nolvadex works by blocking estrogen in breast tissue, slowing or stopping the growth of hormone driven tumors.
Nolvadex is available in 10 mg and 20 mg tablets. Because generic tamoxifen is widely available, many people compare pharmacy prices for cheap options or buy refills online from licensed U.S. pharmacies. Any purchase should be from a legitimate source with clear labeling, correct strength, and a valid expiration date.
Tamoxifen attaches to estrogen receptors on breast cancer cells, blocking estrogen from binding and stimulating cell growth. In breast tissue, this leads to reduced tumor growth and lower recurrence risk. In other tissues like bone and the uterus, tamoxifen may act like estrogen, which can have both benefits and risks.
Nolvadex can also lower the chance of breast cancer in women who are at high risk but have never had the disease. It is not chemotherapy—it works by hormone modulation rather than directly killing cancer cells.
Most benefits are not immediately felt. Over time, Nolvadex reduces the risk of cancer returning and may improve survival in those treated for hormone receptor positive breast cancer.
The usual adult dose is 20 mg once daily, with or without food. Treatment often continues for 5 years, and in some cases up to 10 years, depending on your oncologist’s plan. Some patients may take 10 mg twice daily if better tolerated.
Take Nolvadex at the same time each day. Swallow tablets whole with water. If you miss a dose, take it when remembered unless it is near your next scheduled dose—then skip the missed one. Do not double up.
Generic tamoxifen is inexpensive and widely available. Buying from licensed online pharmacies can reduce costs. Cheap pricing is fine when labeling and expiration dates are clear, and a pharmacist is available for questions.
Common side effects include hot flashes, night sweats, vaginal discharge, irregular periods, and leg cramps. These are related to changes in estrogen activity and may lessen over time.
Nolvadex should be used with caution in people with a history of blood clots, stroke, or liver disease. Regular gynecologic exams are recommended for women, especially those who are postmenopausal. Tell your clinician if you experience leg swelling, chest pain, shortness of breath, or vision changes.
Take Nolvadex exactly as prescribed for the full duration recommended by your oncologist. If buying online, choose licensed U.S. pharmacies, verify labeling and expiration dates, and ensure a pharmacist is available. Cheap pricing is acceptable when those checks are met.
Most people take it for 5 years, but some may benefit from up to 10 years of therapy based on their cancer risk and doctor’s advice.
Yes, it can reduce the risk of developing hormone receptor positive breast cancer in high risk women who have never had the disease.
Take it when remembered unless it is almost time for your next dose. If so, skip the missed dose and continue your regular schedule. Do not double up.
It can cause hot flashes, night sweats, and menstrual changes due to its effect on estrogen receptors.
Some antidepressants, especially paroxetine and fluoxetine, can reduce Nolvadex’s effectiveness. Your clinician may recommend alternatives.
Yes, if purchased from a licensed U.S. pharmacy with clear labeling and expiration dates. Cheap pricing is fine when those checks are met.
Yes, it can slightly increase the risk of deep vein thrombosis and pulmonary embolism, especially in people with other risk factors.
Yes, it can be prescribed to men with certain types of breast cancer or for other hormone related conditions under medical supervision.
Report leg swelling, chest pain, sudden shortness of breath, abnormal vaginal bleeding, or vision changes immediately.
Some people report weight changes, but these are often due to other factors like menopause, cancer treatment, or lifestyle changes.
This website provides informational overviews of medications and does not offer medical advice, diagnosis, or treatment. Always consult a licensed healthcare provider before starting or changing any medication.
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This page was last medically reviewed: August 2025
Educational information only. Nolvadex should be used under clinician supervision, with regular monitoring for side effects and cancer recurrence.